Hemp and other plant-based compounds could be future of contrast-enhanced imaging
Experts are developing plant-based contrast agents they say can enhance imaging studies without the risks associated with traditional contrast media.
PhD candidate Pragati Rout and her mentor, chemistry professor Greg Sotzing, both with the University of Connecticut, have been piloting a study into the potential for hemp to serve as the base for alternative imaging agents. The chemistry duo contend these compounds, which light up naturally under UV light, are nontoxic, biodegradable and do not carry the risk of triggering allergic reactions or kidney damage in vulnerable patients.
Together, they started a company called 404 Inc., which was created to research, develop and market plant-based fluorescent materials that can be used for imaging, in textiles and more.
“We are being exposed to unsafe chemicals when essential imaging techniques are required for diagnosis,’’ Sotzing told UConn Today. “CT contrast agents work, but at the expense of the patients’ future health, that could take the form of a severe rash or kidney damage. 404 Inc. plans to replace these unsafe chemicals with safe contrast agents derived from a natural resource.’’
The researchers are optimistic about the potential of their work, but they acknowledge there are numerous clinical and regulatory hurdles to overcome before their products reach clinical settings. Still, they believe their products could reach the market within the next seven years.
The company currently has its eyes on the upcoming Wolff New Venture Competition, which is offering a prize pool of $150,000 to be divided among competing startups later this month. Rout and Sotzing say any winnings will go toward establishing a lab and hiring consultants to eventually launch clinical trials.
Learn more about their work here.
In addition to her background in journalism, Hannah also has patient-facing experience in clinical settings, having spent more than 12 years working as a registered rad tech. She began covering the medical imaging industry for Innovate Healthcare in 2021.