As the sheer volume of medical imaging data across U.S. healthcare continues to soar, and as burgeoning technologies like AI and enterprise imaging continue to gain altitude, imaging informatics professionals working in healthcare find themselves challenged to keep up. For this reason, many repeat attendees of the annual meetings of the Society for Imaging Informatics in Medicine are likely to find SIIM 2018 among the most consequential in memory. Cheryl K. Carey, MBA, the organization’s new executive director—installed last November—took questions from RBJ during the runup to the event.